Pathophysiology

AA Amyloidosis is a reaction that occurs from a reaction to another illness like chronic infection or chronic inflammatory disease. It's the deposition of amyloid A protein (AA protein) in various tissues and organs.

Medical Diagnosis

Laboratory Tests
Complete Blood Count (CBC): To check for anemia or signs of infection.
Liver Function Tests: To assess liver involvement.
Renal Function Tests: To check for kidney damage (e.g., elevated creatinine or urea levels).
Urinalysis: To detect proteinuria (protein in the urine), which is a common sign of kidney involvement.

Imaging Studies
Ultrasound: To evaluate organ size and detect abnormalities in the liver, spleen, and kidneys.
Echocardiography: To assess heart function and check for amyloid deposits in the heart.
MRI or CT Scan: To provide detailed images of affected organs.

Signs and Symptoms

Enlarged spleen, liver or thyroid.
High cholesterol.
Protein in the urine.
Swelling of ankles/legs.
Low blood pressure upon standing.
Weight loss or Weakness.
Diarrhea/Constipation.
Renal Failure.

Treatment

The effectiveness of treatment for AA amyloidosis largely depends on early diagnosis and the successful management of the underlying cause of inflammation.
Pain relievers.
Drugs to manage diarrhea, nausea, and vomiting.
Diuretics to reduce fluid buildup in your body.
Blood thinners to prevent blood clots.
Medications to control your heart rate.